Investor Presentaiton

39 Werner Helicase is Synthetic Lethal with Microsatellite Instability Targeting Development Candidate in H2 2023 Discovery of Potent and Selective WRN Inhibitors Werner Helicase Inhibitor Drug Discovery Solved >85 X-ray Co-Crystal Structures D2 τα D2 D1 Achieved >10,000,000-fold Affinity Increase Initial Hits Improved Inhibitors High Affinity Poor Druglike Properties Good Druglike Properties Low Affinity Mean tumor volume (mm³) In Vivo Efficacy and Selectivity* 1500 MSI-H 750 Vehicle WRNi % Activity wrt DMSO control D2 τα D2 D1 Biochemical activity across Target Class* 120- 100- 80- 60- Pangenomic Cellular Activity Correlation^ 10 9 8 WRN BLM ✰ RecQ1 RecQ4 RecQ5 (b)001- WRN ⚫ PRISM AUC 3 2 40- 20- 0+ 0.0001 0.001 0.01 0.1 1 10 100 1000 IDB WRNI (μM) -0.35 -0.25 -0.15 -0.05 0.05 0.15 0.25 Nanomolar potency only against WRN Pearson correlation CRISPR Knockouts Sensitivity to WRNi correlates most strongly with WRN gene dependency across the CCLE * IDEAYA / GSK Data: AACR 2023, M. Fischer et. al. ^ IDEAYA / GSK / Broad Institute Data: AACR 2023, M. Fischer et. al. Mean tumor volume (mm³) 0 2500 MSS 1250 20 Treatment day 40 Vehicle WRNi 10 Treatment day 20 IDEAYA BIOSCIENCES

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