Investor Presentaiton
Syphilis Update: Management
Penicillin G, administered parenterally, is the preferred drug for treating
patients in all stages of syphilis
Preparation used (i.e., benzathine, aqueous procaine, or aqueous crystalline)
including dosage, and treatment duration depend on:
i.
the stage; and
ii. clinical manifestations
Treatment for Primary, Secondary, & Early Latent is Benzathine penicillin G 2.4
million units provided as a deep IM single dose (Bicillin L-A®) - two syringes
In cases of penicillin allergy, Doxycycline 100 mg orally twice daily for 14 days
Alternative agents (exceptional circumstances)
Ceftriaxone 1 g IV or IM daily for 10 days
Source: Kimberly A. Workowski et al., Sexually Transmitted Infections Treatment Guidelines, 2021, MMWR. Recommendations
and Reports: Morbidity and Mortality Weekly Report. Recommendations and Reports, vol. 70, 2021,
doi:10.15585/mmwr.rr7004a1.
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Saskatchewan
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