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Investor Presentation

10 Investor presentation First six months of 2022 Rare disease sales were unchanged at constant exchange rates DKK billion Reported Rare disease sales Growth at CER 12 0% 3% 1% 10 8 6% 3% -5% 6 Rare blood disorders • 4 2 0 Total1 Rare blood disorders² Haem. A Haem. B Novo- SevenⓇ Rare endocrine disorders³ Rare disease sales driven by global commercial execution Rare disease sales remain unchanged, driven by: • 1% sales decline in North America Operations • 1% sales growth in International Operations Rare blood disorders sales increased by 3%, driven by: NovoSevenⓇ Uptake of launch products EsperoctⓇ and Refixia® Rare endocrine disorders sales decreased by 5% driven by: • North America Operations sales declined by 14% • Novo Nordisk is the leading company in the global human growth disorder market with a value market share of ~34.0% Source: Quarterly company announcement 1 Total includes "Other Rare disease", which consists of primarily Vagifem® and Activelle®: 2 Comprises NovoSeven®, Novo Eight®, Esperoct®, Refixia® and NovoThirteen®; 3 Primarily NorditropinⓇ. Note: NovoThirteenⓇ is not shown for Rare blood disorders breakdown, only for the total bar. Haem. A: Haemophilia A; Haem. B: Haemophilia B; Unless otherwise specified, sales growth is at constant exchange rates Novo NordiskⓇ
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