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Investor Presentaiton

126 Investor presentation Full year 2022 Rest of World at a glance Million Diabetes trend in population Diabetes market by value and Novo Nordisk market share Rest of World Novo Nordisk reported sales 300 250 18% 200 150 286 40 227 100 187 50 DKK 21% billion Full year 2022 Sales (mDKK) Growth² Total GLP-13 7,604 78% 88 80 80% Long-acting insulin4 2,610 11% Premix insulin5 2,489 5% 60 Fast-acting insulin 2,428 11% 60 34%1 GLP-1 60% Human insulin Insulin 2,713 -4% 2%1 Total insulin 10,240 5% 40 40% Other Diabetes care? 530 11% Diabetes care 18,374 26% 5%1 OAD 20 20 20% Obesity care8 2,138 61% Diabetes & Obesity 20,512 29% 0 2021 0 0% care 2030 2045 Nov 2017 Nov 2022 Population with diabetes Diabetes growth rate Rare disease⁹ Total 4,890 5% 25,402 24% GLP-1 MS -Insulin MS -OAD MS Diabetes trend estimates based on the following International Diabetes Foundation defined regions: South & Central America, Southeast Asia Source: International Diabetes Federation: Diabetes Atlas 10th Edition 2021 1 CAGR calculated for last 5-year period Competitor insulin value market shares, as of Nov 2022: Novo Nordisk 58%, Sanofi 24% and Eli Lilly 13%; Competitor GLP-1 value market shares, as of Nov 2022: Novo Nordisk 73%, Eli Lilly 26% and AstraZeneca 0.4% OAD: Oral anti-diabetic; MS: Market Share; Source: IQVIA MAT, Nov 2022 value figures 2 At constant exchange rates; 3 Comprises Victoza®, OzempicⓇ and RybelsusⓇ; 4 Comprises TresibaⓇ, XultophyⓇ and LevemirⓇ; 5 Comprises NovoMixⓇ and RyzodegⓇ 6 Comprises NovoRapidⓇ and FiaspⓇ:7 Comprises NovoNormⓇ and needles;; 8 Comprises SaxendaⓇ: 9 Comprises primarily Esperoct®, Refixia® ,NovoSeven®, Novo Eight® and Norditropin®
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