Investor Presentaiton

14 Cardiovalve Initial Clinical Results 90% secondary MR pts, 80% pts with heart failure hospitalization in past year Age (years) Baseline Characteristics (N=11) R 启明医疗 VENUSMEDTECH 73±6.2 STS (Avg, Min, Max) 7 (2,16) Etiology Secondary MR 90% (10) NYHA III/IV 90% (10) Mixed 10% (1) Prior HF Hospitalization in past 80% (9) Severe MR 100% (11) year (%) Prior cardiovascular surgery (%) 45% (5) Atrial Fibrillation(%) 77.2% (8) The occurrence rate of LVOT obstruction in TMVR 9.3%*, Cardiovalve post- operation LVOT obstruction 0%; procedure completed 100% Procedure Parameters (N=11) LVOT Obstruction (%) 0% (0) Procedure Completed (Device Implanted) (%) 100% *Core Lab assessment Source: TMVR introduction and challenges (I), AP-SHD, 20190916

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