Investor Presentaiton

Cardiovascular milvexian Camzyos MYK-224 Significant unmet need remains in HFpEF HFrEF Normal HF affects -6.8 million individuals in the US1 HF is classified by clinical signs & symptoms Systolic Heart Failure Normal Heart • . as well as the heart's ability to eject blood 50% of HF patient have HFpEF which is a heterogenous disease contributed to by several comorbidities and/or specific causes, e.g., cardiomyopathy² Patients with HFPEF typically present with dyspnea and evidence of congestion. There may be evidence of diastolic dysfunction, ventricular stiffening and hypertrophy Less blood pumped out of ventricles HFPEF, heart failure with preserved ejection fraction; SGLT-2i, sodium-glucose cotransporter-2 inhibitors. Heidenreich PA et al. J Am Coll Cardiol. 2022 Bristol Myers Squibb 1. 2. Solomon SD et al. NEJM. 2022 HFPEF Diastolic Heart Failure Less blood fills the ventricles Not for Product Promotional Use 123

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