Comera Investor Presentation Deck

mAb liquid formulation development Rh (nm) 100 90 80 70 60 50 40 30 20 10 0 0 ● ● 5 DLS screening to identify stabilizing excipients Isothermal Accelerated stress screening at 45C DLS isothermal screening @40C www 10 15 20 25 Time (h) 30 35 40 45 Selected excipients % monomer 100 90 80 70 60 50 40 30 20 10 0 No stabilizer 4week isothermal Monomer loss 400 mM stabilizers CS1+ CSS CS1+ CS3 CS1 CS1+CS4 CS3 Sucrose CS3+Cs4 Trehelose Stabilizers Comera LIFE SCIENCES Mixtures were observed to improve stability better than single excipients 18

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