Bionomics IPO Presentation Deck

Harnessing the Power of a Novel Neuromodulatory Mechanism 잇 Action of BNC210 depends on Acetylcholine neurotransmission and Allosteric Modulation of a7 nACHR Bionomics AACR iconic Acetylcholine Receptor NAM-Negative Adostric Modulator Co-Calcium ion ACh-Acetylcholine Fr Hippocampus Prefrontal Cortex- Forebrain ACH Ca Amygdala NORMAL BNC210 a7nACH Receptor INFLUX NORMAL MOOD Hippocampus Prefrontal Cortex Basal Forebrain Amygdala ANXIETY & PTSD MOOD DISORDERS BNC210 INFLUX 0:0 INFLUX BNC210 RESTORES NORMAL MOOD NAMS have self-limiting activity determined by the cooperative interaction between BNC210 and Acetylcholine binding at the allosteric and orthosteric sites, respectively 8

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