Bionomics Investor Presentation Deck

Kv3.1 / Kv3.2 Ion Channel Activators for Cognitive Dysfunction and Negative Symptoms Promising therapeutic strategy for improving cognitive disfunction and social withdrawal symptoms -600 COMPOUNDS SYNTHESIZED Bionomics 2 SERIES PATENTED Lead Compound BL-76 Back-up Compounds 2 Patents Published Bionomics' molecules target Kv3.1/3.2 ion channels on parvalbumin positive, gabaergic interneurons in the pre-frontal cortex Spontaneous a Ite rn a tion (%) 80 40 20 Potential in schizophrenia, Autism Spectrum disorders and conditions with cognitive impairments 0 Lead Compound BL-76 Fully Reverses PCP-induced Cognitive Deficit in Mice in the T-maze 100% -0% -75% -43% - 70% - 103% REVERSAL OF PCP EFFECTS Vehicle PCP 3 mg/kg sc Risperidone 0.001 mg/kg ip /P C P BL-7 6 3 m g/kg po/P C P BL-7 6 1 0 mg/kg po/P CP BL-76 30 m g/kg po/P C P 35

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