Vaxcyte Corporate Presentation

17 (2) IgG Titers Limitations of Current PCVS Coverage Expansion Using Conventional Chemistry Has Led to Carrier-Induced Immune Suppression • - Carrier Suppression Reduced immune response to the target polysaccharides due to the cumulative amount of the protein carrier Expanded spectrum of coverage requires increasing protein carrier burden Reduced immune responses demonstrated in both infants and adults о Infant Immune Responses (IgG): Prevnar 7 vs Prevnar 13 (1) Adult Immune Responses (OPA): Prevnar 13 vs PCV20 (2) 33% PCV7 IPCV13 6 % Drop 32% 30% 30% 2000 24% 25% 35% PCV13 PCV20 % Drop 30% 20% 20% 20% LO 19% 20% 1500 17% 17% 23% 17% 16 25% 16% 156 15% 14% 15% T 20% 1000 15% 10% N L 10% 500 5% 1 5% 0 0% 0 0% 4 6B 23F 9V 18C 19F 14 6A 1 19A 19F 4 6B 23F 5 18C 3 7F 9V 14 (1) Yeh et al, Pediatrics. 126: e493 (2010). Prevnar 20 BLA Clinical Review Memorandum. STN: 125731/0 June 8, 2021 % Drop PCV 20/PCV 13

View entire presentation