Valo SPAC Presentation Deck
Therapeutic design: Opal is designed to simultaneously optimize for target
activity, ADME, and tox, moving from a serial to a parallel process
TRADITIONAL DEVELOPMENT
Traditional molecule discovery methods
screen for tox and modify compounds in
a linear, serial fashion¹
Valo
Compound
screening
In vitro
efficacy
101
In vivo
efficacy
Tox screen
VALO INTEGRATED DEVELOPMENT
Opal is designed to make computational
predictions in parallel with molecule design
to generate better optimized compounds in
each cycle
Valo's parallelized design cycle
Experimental
confirmation
Molecule
design
Integrated
design
Data
Tox & ADME
prediction
EXAMPLE PARALLELIZED DESIGN²
CYCLE 1
25 compounds
synthesized
Key activity
goals met
CYCLE 2
31 compounds
synthesized
Key off-targets
modeled
CYCLE 3
13 compounds
synthesized
All optimization
goals met
[1] Hughes, James P., et al. "Principles of Early Drug Discovery." British Journal of Pharmacology 162.6, 1239-1249 (Mar 2011)
[2] Aggregates historical data from acquisitions and work conceived and/or advanced by Valo; Valo does not have ongoing rights related to clinical drug program developed prior to Valo's acquisitions
OT
от
от
OT
CRES EFFET
100%
50%
LORES EFFET M
100%
50%
OT
MOAR
100%
50%
THERAPEUTIC
DESIGN
VORES REP 104
STUR
UCRES P104
STMRE
2Q21
CACO2 ABS
UCES EFFET
ST
CACOS A
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