Kymera Investor Presentation Deck

39 year old Black Female with Moderate HS (HS-PGA); Baseline AN count = 5 Prior treatments: benzocaine ointment Efficacy Endpoints HS-PGA Score AN Count (% Reduction) Skin Pain NRS - Worst, past week (% Change) Peak Pruritis NRS - past week (% Change) HS Case Study: Patient HS-10 Improvement in Disease Severity from Moderate to Mild BL Moderate 5 8 10 Day 28 Mild 2 (-60) 3 (-63) KYMERA ©2023 KYMERA THERAPEUTICS, INC. 2 (-80) Day 35 Mild 2 (-60) 3 (-63) 0 (-100) Day 42 Mild 1 (-80) 1 (-88) 0 (-100) Day 1 - BL Percent Change from Baseline Multiple Ulcerated 40 Plasma Cytokines/Acute Phase Reactants 20 O -20 -40 -60- -80 Nodules O 7 14 21 28 Day Day 42 Clearing of Ulcerated Nodules 35 IL-1B SAA 42 49 PAGE 29

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