Akouos IPO Presentation Deck
The Anatomy and Biology of the Inner Ear Are Ideal for
One-Time Genetic Medicines
12
Opportunity to Leverage Learnings from
Development of Genetic Medicines for the Eye and Brain
Eye
.
Brain
Inner Ear
CONFIDENTIAL
.
AKQUOS
Unique Advantages
of the Inner Ear
• Fewer target cells and smaller
delivery volume → less vector
required for meaningful
transgene expression
Enclosed compartments → opportunity for local, targeted delivery
Reduced immune surveillance → lower impact of neutralizing antibodies
Non-dividing target cells → potential for one-time delivery to provide life-long benefit
Anatomy is fully developed at
birth more favorable
benefit-risk profile in pediatric
populations
While the unique anatomical challenges of delivering to the inner ear have hindered genetic medicine development for
hearing disorders, we believe Akouos is uniquely positioned to overcome these delivery challengesView entire presentation