BioNTech Investor Day Presentation Deck
BNT312 strengthens crosslinking between T cells and APCs
DAPI
LEAT
Phalloidin
Z-projection on the y
Z-projection on the x
Single Z plane of iDC cocultured with preactivated CD8+ T cells in the
presence of Alexa Fluor 647-conjugated DuoBody-CD40.4-1BB (magenta) and
LFA-1 (green) antibodies, on the x and y axes the z-stack of the same picture
with the relative zoom in. Nuclei were counterstained with Hoechst (blue)
BNT312 (Gen1042) is partnered with Genmab based on 50/50 sharing of costs and profits.
Muik A, et al. J Immuno Ther Cancer 2022; 10:e004322.
Strengthened
crosslinking
10 μm
Hoechst
bsAb-ctris (CD40+ 4-1BB)
LFA-1
Hoechst
Protein therapeutics
DuoBody-CD40x4-1BB
10 μm
Representative fluorescent images of cocultures in the presence of
DuoBody-CD40.4-1BB or control antibodies.
White dashed line = interface between DC and T cell
LFA-1
BIONTECH
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