Ocuphire Pharma Investor Day Presentation Deck
P
VEGA-1: Functional Vision Durability
Single Drop of Nyxol has Durable Response for 18 Hours
18 hours post
Nyxol
consistent
efficacy with 12
hours
94
0.75%
Nyxol
Subjects achieving 3-line gain in photopic, binocular
DCNVA (N=30)
Time Point
(Hrs post Nyxol dose)
12.5
18
Nyxol as a Single Drop
18
% of Subjects
33%
37%
Subjects achieving 20/40 or better in photopic,
N/A
binocular DCNVA (N= 30)
(compared to baseline)
*Trend toward statistical significance even in smaller Nyxol arm from time 0 to time 6 hrs (n=30); larger sample size for all arms planned in Phase 3 program
Statistics vs Placebo
60%
p=0.07*
p=0.11*
VEGA-1 TLR Table 14.2.1.2 Percent of Subjects with Photopic DCNVA by Time Point (PP Population) and Table 14.2.24.1 Percent of Subjects with Photopic DCNVA by
Time Point (PP Population)
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