Kymera Investor Day Presentation Deck
Kymera has Engaged a Broadly Expressed Protein in Only One Cell
Type Using a Tissue Selective E3 Ligase
Protein
Kymera Has Identified an E3 Ligase
that is Expressed Almost
Exclusively in One Cell Population
CRBN
Ligase X
Biological
Replicates
Protein Expression Profile
(Proprietary E3 Atlas)
Target
Cells
1 23
Cell #1
1 2 3
Cell #2
Log 10
Tox Cell Types
1 2 3
Cell #3
Concentration
Estimate [nM]
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1 2 3
Cell #4
1
2
1
2 3
Cell #5
Ligand
Identification
and
Optimization
Small Molecule Ligand Bound
to a Tissue-selective E3 Ligase
KYMERA R&D DAY - December 16th, 2021
Lead Compound
Affinity K = < 1 uM
Leads to an Active Ternary Complex
with a Protein of Interest
Relative Signal
1.0
0.5
0.0
AUC 1.133
Bmax=1109 nM
-9 -8 -7 -6 -5 -4
Log[Compound], M
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