Kymera IPO Presentation Deck
CANCER
FIBROSIS
Liquid Tumors
KYMERA
Autoimmune
Fibrosis
STAT3 Protein (% Control)
STAT3 Degradation
150
125-
100
50
STAT3 Degradation and Downstream Effects
Across Tumor Cells
25
-SU-DHL-1
SUP-MZ
0 1 2 3
Log [STAT3 Degrader] (nM)
• STAT3 protein levels measured in two
STAT3-dependent cell lines
• STAT3 degrader decreased levels of
STAT3 by greater than 95% with DC so of
15nM and 86 nM, respectively
Gene Transcription Effects
mRNA Levels (% Control)
125
100
75
50-
25
Socs3
+Myc
0 1 2 3
Log (STAT3 Degrader] (n)
Expression of STAT3 downstream target
genes in SU-DHL-1 cells measured
Treatment with STAT3 degrader for 24
hours led to significant downregulation
of STAT3 target genes, including SOCS3
(ICS = 36 nM) and MYC (IC=37 nM)
Growth Inhibition (% Control)
Cell Viability Effects
125
100-
75-
50
25-
-SU-DHL-1
SUP-M2
-1 0 1 2 3 4
Log [STAT3 Degrader] (nM)
5
Impact of STAT3 degradation on
viability of lymphoma cells measured
. Inhibited growth of SU-DHL-1 and SUP-
M2 cells with IC50 values of 64 and 105
nM, respectivelyView entire presentation