23andMe Investor Presentation Deck

How Ancestry Matters In Connection To Your Health Current clinical guidelines and eligibility for insurance coverage limit BRCA testing to women with a personal or family history of cancer (Robson, 2003) Ann M. 23andMe Customer Ann did not know her ancestry origins and would not have been eligible for clinical testing under current guidelines. Ann decided to do 23andMe to learn more about her potential health risks. Based on her 23andMe report, she discovered she had a BRCA1 mutation. Her doctor confirmed the results and she opted to have surgeries to reduce her risk of having ovarian and/or breast cancer. ¹ NCCN is the National Comprehensive Cancer Network® (NCCNⓇ). 20% Adult individuals with a BRCA1 or BRCA2 variant Meet NCCNⓇ criteria¹ Identified by healthcare system 50% 80% Missed by healthcare system KKK DTC Testing Do not meet NCCN® criteria 45% 21% 50% KK No first-degree family history of a BRCA-related cancer Did not self-report having Jewish ancestry Copyright © 2022 23and Me, Inc. 23and Me 14

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