Akouos IPO Presentation Deck

AAVAnc80 Efficiently Transduces Multiple Cell Types in the Inner Ear 20 • Conducted preclinical studies across three different non-human primate models using GFP as a reporter gene delivered by AAVAnc80 • AAVAnc80 can efficiently transduce multiple target cell populations throughout the cochlea in the primate inner ear • Pre-existing neutralizing antibodies, even at relatively high levels in serum, did not inhibit cochlear cell transduction following intracochlear delivery CONFIDENTIAL Treated Untreated Hensen's Cells Outer Hair Cells Pillar Cells Inner Hair Cells Inner Border Cells GFP Hensen's Cells Outer Hair Cells Pillar Cells Inner Hair Cells Inner Border Cells b Myo7a GFP Outer Hair Cells Pillar Cells Outer Hair Cells Pillar Cells Satellite Glial Cells AKOUOS GFP Hoescht GFP Tu

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