Dare Bioscience Investor Presentation Deck
DARE-GML
Glycerol monolaurate (GML) is a naturally occurring fatty acid monoester that has shown broad antimicrobial activity, killing bacteria,
fungi and viruses, and represents a new class of antimicrobial agents.
GML has the potential to be a first-in-category multi-target antimicrobial.
Bacterial vaginosis and vulvovaginal candidiasis represent the two most common vaginal infections in the
United States, leading to over 30 million treatment visits per year 1,2
Women often experience multiple episodes of vaginal infection in a year, and treatments for one condition may increase the likelihood of
developing another condition.3 GML has multiple properties that make it an attractive active pharmaceutical ingredient (API) to potentially treat
and/or prevent vaginal infections of various sources.
1. Proven activity against the key culprit microbial species (Gardnarella and Candida) that cause most vaginal infections4
2. Potential to inhibit bacterial biofilm formation and disrupt already formed biofilms5
3. Unique microbicidal mechanism of action, targeting bacterial surface signal signaling by plasma membrane disruption, potentially
preventing development of microbial resistances
GML has been shown both in vitro and in women to reduce both bacterial and fungal colonization without affecting the healthy bacteria
that maintain vaginal health and has also been shown in vivo to inhibit viral transmission.6
1. https://www.cdc.gov/std/bv/stats.htm
2. Benedict K, Jackson BR, Chiller T, Beer KD. Estimation of direct healthcare costs of fungal diseases in the United States. Clin Infect Dis. 2018 Sep 10.
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827160/
4. Antimicrob Agents Chemother. 2010 Feb;54(2):597-601
5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394780/
6. 2009. Glycerol monolaurate prevents mucosal SIV transmission. Nature458:1034-1038.
49View entire presentation