BioNTech Investor Day Presentation Deck
2 Variant-adapted vaccines
Omicron has more sublineages than all other variants combined
Larger clades in GISAID were named in context of marker
variants relative to WIV04-reference:
s CR7821,128144C includes N58-L845
LC241.C3037 A23403,08782,011091,025563,626144,728144.628882 (W/VD4-
reference)
V G110911025144T includes NSP6-L37F+NS3-4251V
G C2411,C30377 423405G 5-D6146
GK C2417,C30377 A23403G,C22995A includes 5 0614G-ST478K
GH C2411 C30371,A23403G GISS563T includes 5-06340 N53 Q57H
GV C2437 C30371,A234036 C22227T includes S-06140 +5-AZ22V
GR C2417C30371 A23403G G28882A includes 5-06140-N-G204R
GRY C241T C10371,21765 21770de21991-21995ddl A210631 A234030,G28882A
includes del S-V70del S-Y144del S-N501Y+S-D5140+N-02018
GRA: C243T.C30371,A234035,628882A includes 5-0614G+N62048 (at (ezt & of
the following amino acid changes S-V143del S-V145del,S N211del, ins214PES
03390,5-537115-5477NS-T4785-8484A,S-QASES-C4,575475525
P681HS-P68115-N764K5-0796Y-NS50K,S-Q954HS-N90965-1981)
GRA
Omicron
Neighbor-Joining tree with
fasttree visualized in ete3.
L
Clade references and Pango lineages
OVAS A BUTC-00200035482070-44-28
OBCH/C
GISAID Initiative database: https://www.gisaid.org/ (accessed June 22, 2022).
471022003, 43452020-02
#£111208C-Irgand 2010042003-
Or Au 811720 CW-16--23
AC 821 2022 202-11-
SKELETON
2013-04-2
ANC-2020-15-30
LEBLOW-4/2402104208-0-31
LEA 202010-05-14
GH
Beta
GR
GRY Gamma
Alpha Blue: Asia
20-12-2
S
GV
GK
Delta
Green: new from Oceania
Magenta: new from Americas
Red: new from Europe
Yellow: new from Afrien
Grey: from previous updates
Sampled genome
tree derived from all
outbreak sequences
2022-06-21
Notable changes
10,424,471 full genomes (+85,020)
(excluding low coverage, out of 11,433,557
entries)
S clade [#RBDx] 16,478 [6,334]
(+1 [+1])
L clade (#RBDx] 5,977 [144]
(+9 [+0])
V clade [#RBDx] 6,687 [41]
(+1 [+0])
G clade [#RBDx] 288,883 [120,306] (+178
[+20])
GR clade [#RBDx] 475,918 [247,819]
(+165 [+86])
GRY clade [#RBDx) 1,031,623 [113,225]
(+65 [+4])
GH clade [#RBDx] 508,442 [233,686]
(+230 [+23])
GV clade [#RBDx] 171,815 (9,712] (+6
[+5])
GK clade [#RBDx] 4,051,491 [637,802]
(+2,353 [+430))
GRA clade 3,823,229 (+81,980)
Other clade [#RBDx] 43,919 [30,263]
(+32 [+5))
We gratefully acknowledge
the Authors from Originating
and Submitting laboratories
of sequence data on which the
analysis is based.
GISAID
by BII/GIS, A STAR Singapore
Omicron mutanome continues
to rapidly expand
Pandemic prep.
Omicron sublineages continue
to show increased immune
escape properties
[DAN
Omicron sublineages have
become mutationally distinct
CAR
Pfizer BIONTECH
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