BioNTech Investor Day Presentation Deck

2 Variant-adapted vaccines BA.2.12.1 and BA.4/5 are now increasing in prevalence Proportion of Strains 100 75 DOM Aug 2021 Oct 2021 Sampling Date 50 25 0 Feb 2021 Apr 2021 USA circulating strains trend Jun 2021 GISAID Initiative database: https://www.gisaid.org/ (accessed May 31, 2022). Dec 2021 Feb 2022 Apr 2022 Jun 2022 Alpha Beta Delta Gamma Omicron BA.1 Omicron BA.2 Omicron BA.2.12.1 Omicron BA.4 Omicron BA.5 [DAN Pandemic prep. CAR Pfizer BIONTECH 75

View entire presentation