Taysha IPO Presentation Deck

Safety: Intrathecal TSHA-102 was not associated with early death in WT mice % Survival 100 80 60 40 20 0 0 0 vg, n=13 1x10¹1 vg AAV9/mini, n=12 1x10¹2 vg AAV9/MECP2(v2), n=6 1x10¹2 vg TSHA-102, n=9 5 10 15 Diamond = vet-requested euthanasia for prolapse or bullying-related injury 20 1x10¹¹ vg AAV9/MECP2(v2), n=12 1x10¹¹ vg TSHA-102, n=12 1x10¹2 AAV9/mini, n=8 Age (weeks) Mice were dosed P28-35 T 25 30 35 00 34

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