Exact Sciences Comapany Presentation

Advancing our pipeline of life-changing tests Colorectal cancer screening (CRC) 110M people in U.S. Multi-cancer early detection (MCED) 135M people in U.S. Molecular residual disease (MRD) 12M annual U.S. testing opportunities Source: U.S. Census data, Exact Sciences estimates; includes U.S. markets only EXACT SCIENCES [ cancerguard™ oncodetect™ Drive profitable revenue Ĉ next-generation cologuard® Invest in world-class talent Provide seamless customer experience Offer tests that impact decision-making 2 Generate rock-solid clinical evidence ✓ Increase access & drive adoption 12

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