Aeglea BioTherapeutics Investor Presentation Deck

SPY001 has exhibited ~2x the half-life of vedolizumab in NHPs DEMONSTRATED EXTENDED HALF-LIFE IN Tg276 MICE SPY001 t1/2: 10 Days Vedo t₁/2 : -3 Days Normalized Concentration (C/Co) 0.1 0.01 0.001 0.0001 --- 0 Source: Data on file. SPYRE 10 19 Days 20 H 30 DEMONSTRATED EXTENDED HALF-LIFE IN NHPs Normalized Concentration (C/C₂) 0.1 0 IGH 15 5 HOHO SPY001 t1/2:17 Days Vedo t1/2 : ~10 Days 10 Days KA Ho 15 20 11

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