Orthofix Investor Presentation Deck

Biologics & Regenerative Technologies Market-leading applications for spine and orthopedic patients BONE GROWTH THERAPIES - NONSURGICAL #1 prescribed bone growth stimulator in U.S. Proven Pulsed Electromagnetic Field (PEMF) technology ● ● ● Pipeline of Low Intensity Pulsed Ultrasound (LIPUS) technology Only FDA-approved cervical treatment indication $600 million market opportunity BIOLOGIC THERAPIES - SURGICAL #1 cellular allograft market share in spine Exclusive partnership with MTF Biologics Expanded portfolio of synthetic solutions $2.1 billion market opportunity ● ● ORTHOFIX 10

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