Kymera IPO Presentation Deck
KYMERA
Whole Body
Binders
Toolbox
Ternary
Complex
Modeling
Quantitative
System
Pharmacology
Model
Proprietary
Pegasus
Ternary Complex Modeling / Quantitative System Pharmacology Model
Refined understanding of
each parameter impacting
degradation profiles
. Modeling predicts how
relative E3 ligase and
protein concentrations
impact degradation
Designed to solve complex
equations to accurately
translate PK/PD into
optimal human dosing
Example 1: Target vs E3 Ligase Concentration Range
Leads to Suboptimal Ternary Complex and Degradation
Temary Complex
Degrader Concentration
Example 2: Target vs E3 Ligase Concentration Range
Leads to Optimal Ternary Complex and Degradation
TERNARY COMPLEX
Degrader Concentration
=
DEGRADATION
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