Akouos IPO Presentation Deck

Access to Multiple Cell Types Opens Large Target Landscape 21 Inner Border Cells Spiral Ganglion Cells Inne Ha Inner Hair Cells Outer Hair Cells Claudius Cells Inner Hair Cells CONFIDENTIAL OTOF SLC17AB SERPINB6 MY07A, POU4F3, CDH23, ESPN, USHIC, TRIOBP, TMC1, MYO1SA, ACTG1, MY06, RDX WHRN, LOXHD1, TMHS.... PJVK KONOA Spiral Ganglion Cells Outer Hair Cells STRC, SLC26A5 AKQUOS Supporting Cells GJB2, GLB3, GJB6, SLC26A4 Different genes are associated with the different cell types in the ear, including inner hair cells, outer hair cells, and supporting cells

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