BioNTech Investor Day Presentation Deck
2 Variant-adapted vaccines
Omicron BA.4/5 RBD and NTD sequences are distinct from BA.1 and BA.2
F486V
BA.4/5 additional
mutations
L452R
RBD top view
R408S
S477N T478K
K417N
D405N
Y505H
T376A
G4905
S375F
Tuekprakhon A, et al. bioRxiv 2022; doi.org/10.1101/2022.05.21.492554.
Q493R
N501Y
E484A
Q498R
S373P
N440K
G446S
S371L/F
R346K
X
N343
glycan X
ACE2
footprint
Common to
BA.1, BA.1.1,
BA.2 & BA.3
BA.1, BA.1.1 &
BA.3 (except 496)
BA.1.1 only
BA.2 only (D405N
Also in BA.3)
S371L: BA.1, BA.1.1
S371F: BA.2, BA.3
not in BA.4/5
not in BA.3
A67V,A69-70,T951,G142D,A143-145,N2111,A212,
A67V,A69-70,T951,G142D,A143-145,N2111,A212,
G142D,
BA.1
BA.1.1
BA.2 T191,424-26,A27S,
BA.3
BA.4/5 T191,A24-26,A27S,
A67V,A69-70,T951,G142D, A143-145,N2111,A212
A69-70, G142D,
$371L,S373P,S375F,
BA.1 G339D,
BA.1.1 G339D,R346K,S371L,S373P,S375F,
BA.2 G339D,
BA.3 G339D,
BA.4/5 G339D,
BA.1
BA.1.1
BA.2
BA.3
BA.4/5 L452R,S477N,T478K, E484A,F486V,
S477N,T478K,E484A,
S477N,T478K,E484A,
S477N,T478K,E484A,
S477N,T478K,E484A,
S371F,S373P,S375F,T376A,D405N, R408S,K417N, N440K
S371F,S373P,S375F,
D405N, K417N,N440K, G446S
S371F,S373P,S375F,T376A, D405N, R408S,K417N, N440K,
V213G
Q493R,
Q493R,
V213G
Q493R,G496S,Q498R, N501Y,Y505H
K417N,N440K,G446S
K417N,N440K, G446S
Q493R,G496S,Q498R,N501Y,Y505H
D614G,H655Y,N679K,P681H,N746K,D796Y,
D614G,H655Y,N679K,P681H,N764K, D796Y,
Q498R,N501Y,Y505H
Q498R,N501Y,Y505H
Q498R, N501Y,Y505H
Omicron BA.4 and BA.5 contain additional mutations in the RBD, in particular
the reversion mutation R493Q, together with mutations L452R and F486V
BA.1 T547K,D614G,H655Y,N679K,P681H,N764K,D796Y,N856K,Q954H,N969K,L981F
BA.1.1 T547K, D614G,H655Y,N679K,P681H,N764K,D796Y,N856K,Q954H,N969K, L981F
BA.2
D614G,H655Y,N679K, P681H,N764K,D796Y,
BA.3
BA.4/5
ins214EPE
ins214EPE
Q954H,N969K
Q954H,N969K
Q954H,N969K
NUA
Pandemic prep.
NTD
RBD
CAR
Pfizer
Pfizer BIONTECH
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