Taysha IPO Presentation Deck

miRARE is a targeting panel for endogenous miRNAs which regulate MECP2 expression 1 Viral genome in nucleus 2 mRNA in cytoplasm MECP2 Translation and nuclear localization 3 miRNA-responsive target sequence in untranslated region 5 Mature miRNAS bind to mRNA in cytoplasm to regulate its expression MECP2 In this conceptual loop, the 3'UTR features targets for miRNAs. The viral genome does not encode miRNAs. F. mature miRNA miRNA expression MECP2 drives expression of many endogenous miRNAs 00 31

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