23andMe Investor Presentation Deck

1 40 PEMAS MOLT 1095 10974910 1.1 Genetic Association of the TSLP Signalling Pathway With Asthma 110 UN POCOLO 110.5 Position on chrs (Mb) 113077425 Cad10.20 TORR THE MARSAS 19 ROMANA Pon(M) VAADE M C Poston chr( M +++ 13. 65 #1837253 POL *SLAPSAS 1115 7 100 -80 -TSLPR I Cell membrane JAK2 TSLP STAT5 IL-7Ra JAK1 Proinflammatory signaling I I 1 1 647 PLACCALPAY SPERZ 1512687352 35.5 358 Pastion on ches (M) 64.9 - CA 12409033 3+ M UT CAPS MAGLU me JAKT COM PSAC 42.5 05 TUB CORD IN www. ww ONI +THE+BON gra 36 COPERCAL AARS RUNDO IATA UCITIAL RAD 30.1 M 052 TENTA cocam SAY APLAD 435 2892 TSLP is a well-known cytokine with a role in maintaining immune homeostasis and regulating inflammatory responses at mucosal barriers. The TSLP signaling pathway is an attractive therapeutic target. e.g. Tezepelumab, a TSLP-blocking monoclonal antibody for treatment of asthma. Our genetic data shows that multiple genes within the TSLP pathway associate strongly with asthma. Copyright © 2023 23and Me, Inc. 23andMe 33

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