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wwwww Genetic Association of the TSLP Signalling Pathway With Asthma PEST Shang Com -FSŁPR- Cell membrane -JAK2 TSLP STAT5 JAK1 I I I IL-7Ra Proinflammatoly signaling I MAT - - VERE TSLP is a well-known cytokine with a role in maintaining immune homeostasis and regulating inflammatory responses at mucosal barriers. The TSLP signaling pathway is an attractive therapeutic - target. e.g. Tezepelumab, a TSLP-blocking monoclonal - antibody for treatment of asthma. Our genetic data shows that multiple genes within the TSLP pathway associate strongly with asthma. Copyright © 2022 23and Me, Inc. 23andMe 32

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