Evotec Investor Day Presentation Deck
BAYER
evotec
BAYER
Expertise in
inflammation /
Women's
health; market
access
PAGE 33
Sex hormones
Key target in nerve fiber hypersensitization
P2X3 antagonist – Eliapixant (BAY1817080)
Endometriotic lesions
Proliferating
endometriotic cells
Innate immune system
• Innate immune
.. system activation
DAMPS, Iron (OS)
Menstruating tissue Cell death
Direct sensory
nerve stimulation
PGE2, Acidosis (H+),
Iron (OS)
NF-KB
NF-KB.
●
Macrophages
Mast cells
P2X3
Nervous system
response
SP, CGRP
Sensory nerve
stimulation
NGF, IL-1B,
TNF-a, PGE2
P2X3
Peripheral nervous system
Primary sensory
neurons
Nociceptive signal
Sensory nerve endings
Dorsal root
ganglion
Derived from the strategic multi-target research alliance of Bayer and Evotec on endometriosis
Infographic: Modified from Laux-Biehlmann et al, Trends Pharmacol Sci. 2015 May;36(5):270-6.
* RCC: Refractory Chronic Cough
Spinal cord
evotec
Expertise in
pain research,
in vivo; ion
channels
Multi-target
notential
RCC*
Overactive
Bladder
Others e.g. neuropathic
Endometriosis
BAYER
BAYER
pain, ...View entire presentation