Eleusis SPAC
Exploring Psychedelics Beyond Psychiatry - Eleusis Drug Discovery Platform
Discovery Mission
■
Identify new indications beyond psychiatry
and expand new chemistry library
Translation in
Ophthalmology
Efficacy observed in translational
models of allergic conjunctivitis¹,
uveitis², glaucoma and tear
production³
ELE-102 is a topically delivered
drug candidate currently in IND-
enabling preclinical studies
Median of Cumulated Clinical
Scores per Animal
8-
0
Allergic Conjunctivitis¹
Front-of-Eye
2
4
Hours Post 48/80
Translation Mission
Advance a topically delivered therapy
for ocular disease
ELE-01 (0.05%)
ELE-01 (0.01%)
ELE-01 (0.001%)
Saline
8 23 24 25
Antigen-Induced
Uveitis Model³
Posterior Uveitis²
DEGENERATION
NORMAL
Back-of-Eye
CONTROL
Retina
Retina
+ PSYCHEDELIC
Choroid
Choroid
100m
100 μm
eleusis Source: 1) NZW rabbits administered topical ELE-01 6x the day prior, and once 1hr prior the challenge with compound 48/80, which induces histamine release and mast cell degranulation; 4 animals per group, 8 eyes per
group 2) Eleusis sponsored study of topical ELE-01 (0.01%, TID) in TB-induced Uveitis in NZW rabbits 3) Eleusis sponsored university research program
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