Taysha IPO Presentation Deck

TSHA-118/ ABO-202 increases plasma PPT1 Activity in CLN1 mice 105 104 10³ 10² 10¹ <10⁰ Het KO Untreated WT Het Time Post-Treatment: 1.5 to 8.5 months 4 20 26 Treatment Age (weeks) WT-Untreated Het-untreated KO-untreated IT 7x10¹¹ vg/mouse PPT1 enzyme activity was measured in serum at selected timepoints following TSHA-118 delivery by IT administration at 4, 20, or 26 weeks of age Supraphysiological levels of active PPT1 were observed in all TSHA-118 treated mice and persisted through the study endpoint T * 25

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