Immix Biopharma Investor Presentation Deck
3 Optimal Tumor Binding While Ensuring High Expression
COBRA Binder
COBRA Binder
Leads with
Heavy Chain
Proven
Linker of
Heavy and
Light Chain
Employed
..
IHSL
VH (GGGGS)5
LSH VL
(GGGGS) 5
Biomarker Research
VL |--
VH
3.6
Source:: Moreno-Cortes E,. et al Front Oncol. 2023; Mazinani M, et al. Biomark Res. 2022.
1.6
Day 10 CAR-T Expansion
(10^7)
HSL LSH
80
76
Specific Cytotoxicity (%):
JeKo1 (ROR1+) co-culture
HSL LSH
doi: 10.3389/fonc.2023.1200914
"Glycine (Gly) and serine (Ser) residues provide the flexibility necessary
for antigen-binding sites to change conformation and maintain good
stability in aqueous solutions... prevent[ing] formation of secondary
structures and reduc[ing] likelihood of the linker interfering with the
folding and function of the scFv"
September 19, 2022
doi: 10.1186/s40364-022-00417-w
●
●●●
IMMIX
S BIOPHARMA
NXC-201 COBRA
Binder: Heavy Chain
- Proven Linker -
Light Chain
Configuration,
enabling:
Rapid,
Sustained CAR-
T Expansion
✓ Improved
Cytotoxicity in
the presence of
antigen
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