Taysha IPO Presentation Deck

SLC6A1 is a rare neurological condition that causes severe movement and speech disorders The SLC6A1 gene encodes the GABA transporter 1 (GAT-1) Patients with SLC6A1 have a deficiency of GAT-1, resulting in decreased GABA transport and aberrant neuronal activity The symptoms of SLC6A1 typically appear at 3-4 years and progressively worsen with age SLC6A1 has an estimated prevalence of 16,000 patients, which we believe is underestimation as there is an emerging epidemiology AAV9 IDAT hSLC6A1 NU Intrathecal delivery F GAT EAATI Gutamate veul transpor GARA BRIN SHATS 17 Postyc Gal Coll 64

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