Valo SPAC Presentation Deck
Therapeutic design: Opal's proprietary active learning loop is designed to
accelerate programs through the discovery process (target → drug candidate)
OPAL'S INTEGRATED MOLECULE DESIGN LOOP
Opal is designed to make computational predictions in parallel with molecule design to generate better optimized
compounds in each cycle, while performing serial processes in parallel
Molecule Discovery Input Data
>200K ADME data points from >50 endpoint assays
>10M compounds with activity data
>70 trillion virtual molecules created
>375M molecules scored
Predictive Models
Generated by the input data set.
Activity, selectivity, toxicity, metabolism, bioavailability,
synthesizability, etc.
>30,000 models built and deployed
>2 billion predictions made, evaluating against
optimization criteria
In-House Valo Laboratories (>40K sq. ft.)
Automated synthesis + purification of 5,000 molecules/month (average)
DEL libraries of >5B drug-like compounds
4 automated HTS platforms operating up to 24/6
HTS library of >500K compounds
Closed loop structure designed to allow Valo to start anywhere in the process without the typical
limitations of disintegrated Al molecule design
Valo HTS = high throughput screening; DEL = DNA-encoded library; ADME = absorption, distribution, metabolism, and excretion
THERAPEUTIC
DESIGN
2Q21
19View entire presentation