1Q21 Investor Update slide image

1Q21 Investor Update

Q1 DEVELOPMENTS: TOBACCO AND CANNABIS FRANCHISES Tobacco Franchise Steadily raising the intensity and frequency of communications to secure FDA Modified Risk Tobacco Product (MRTP) designation of VLNⓇ across FDA, executive, congressional and state leadership I I Fully prepared for commercial launch of VLN® within 90 days of receiving MRTP designation Expanded VLNⓇ tobacco growing program to support anticipated consumer demand Manufacturing capabilities geared for a strong commercial launch and growth; adding in-house test and measurement capabilities lowers cost, increases speed Willing to license reduced nicotine technology to facilitate a nicotine cap proposal to significantly reduce the harm caused by smoking Hemp/Cannabis Franchise Changing regulations driving market growth, capital investment and increased need for competitive differentiation I ▪ Advancing development of end-to-end upstream cannabinoid value chain capabilities to create disruptive, valuable plant lines ▪ Key partnerships in place to accelerate commercialization of next-gen hemp/cannabis plant lines and IP in as little as two years from trait identification to viable plants ▪ Extended and expanded our exclusive partnership with KeyGene to lock in long-term strategic advantage and future development 22nd Century Group, Inc. Advancing monetization for 2H 2021 from initial plants and IP; readying next generation of plants lines for prospective customers DISRUPTING THE +$1.3 TRILLION GLOBAL TOBACCO, HEMP/CANNABIS MARKETS, AND THIRD PLANT-BASED FRANCHISE (TO BE ANNOUNCED) t
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