Kymera IPO Presentation Deck

CANCER FIBROSIS Liquid Tumors Solid Tumors Autoimmune KYMERA Fibrosis Highly Specific Degradation of STAT3 • Deep mass spectrometry-based proteomics to assess STAT3 specificity performed i hPBMC and tumor cells (SU-DHL-1) treated with Kymera's STAT3 degrader • STAT3 was the only protein to be degraded with statistical significance Data demonstrate highly selective degradation profile p-value (-Log 10) L 3.5 inn 5 1 0.5 DC90 hPBMCs "STAT3 STAT3-85701 CO 24hr pval-0.05 1 2 Protein Level Fold Change (Log2) p-value (-Log 10) m 1.5 0.5 DC90 SU-DHL-1 STAT3 STAT3-A5701 Bhr 1 Protein Level Fold Change (Log2) STAT Family Members: STAT1, STAT2, STAT3, STAT4, STATSA, STATSB, STAT6

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