Evotec Investor Day Presentation Deck

evotec Kidney diseases are very diverse and not well defined More precise definitions and disease models are needed Broad spectrum of kidney diseases • Major category is chronic kidney diseases of unknown etiology Category "Glomerular" includes - Idiopathic membrane nephropathy - Focal segmental glomerulare sclerosis -Alport syndrome - Fabry disease PAGE 56 . Even is the cause is known, treatment is. not always clear Source: ttps://www.nurturebiobank.org/dynamic-data-ckd/ Reflux nephropathy SLE DKD_type 1 Toxic AKI 2% 1% 1% Obstructive nephropathy Circulatory Ischaemic nephropathy hypertensive CKD Other TI_Nephritis 4% 4% 5% 4% Vasculitis 6% 3% IgAN 3% 2% 6% 2% 8% Glomerular 9% Cystic 30% 9% CKD of unknown etiology DKD_type 2

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