Akouos IPO Presentation Deck

AAVAnc80 Exhibits High Transduction Efficiency Compared to Other AAV Capsids 17 Capsid Dose OHCs IHCS AAVAnc80 Transduces Cochlear Hair Cells More Efficiently than Other AAV Capsids AAV8 7x %GFP* IHCs 100 80 60 40 20 0 AAV1 21x AAV1 AAV2 AAV6 AAV8 AAV2 3.5x 8 AAVANC80 Apex Base %GFP* OHCs CONFIDENTIAL 100 80 60 40 20 0 ∞∞ AAV1 AAV2 AAV6 AAVAnc80 1x AAV8 9 AAVAnc80 AKOUOS Landegger et al. (2017), Nature Biotechnology 35, 280-284 Multiple independent investigations have shown increased hair cell transduction efficiency of AAVAnc80 relative to other AAV capsids in mouse and non-human primate models OHCS = outer hair cells; IHCS = inner hair cells; GFP = green fluorescent protein

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