BenevolentAI Investor Day Presentation Deck
We expect BEN-2293 to provide both symptomatic relief
and to reverse disease progression in atopic dermatitis
• BEN-2293 is highly selective for Trk receptors, with IC50
potencies in the low nM range for TrkA, B, and C
• BEN-2293 dose dependently inhibits release of inflammatory Thl
and Th2 cytokines TNFa, IFNY, IL-13, and IL-4 in human peripheral
blood mononuclear cells (PBMCs) stimulated with an inflammatory
T-cell stimulus (anti-CD3/CD28)
• BEN-2293 inhibits the release of Calcitonin Gene-Related
Peptide (CGRP), a mediator of itch, sensory nerve
hypersensitisation and neurogenic inflammation, in dorsal root
ganglion (DRG) isolated from adult rats and stimulated with NGF
• BEN-2293 series significantly (p<0.05) reduced mouse ear
inflammation following administration of PMA, significantly
reducing expression of cytokines IL-1B, IL-4, IL-6, CXCL1, MCP-1, and
Tarc
• BEN-2293 demonstrates excellent tolerability and safety margins
in IND/CTA-enabling toxicology studies
Key: Tropomyosin-related kinase (Trk) receptor tyrosine kinase family, namely TrkA, TrkB, and TrkC;
Nerve Growth Factor (NGF); Brain Derived Neurotrophic Factor (BDNF); Neurotrophin-3 (NTF-3)/NT3
BEN-2293 Inhibition of human primary T-cell activation
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Reduction in mouse ear
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PanTrk (0.5mg)
Dexamethasone (0.1mg)-
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