Certara Investor Day Presentation Deck

Platform approach to quantitative systems pharmacology QSP combines computational modeling and experimental data to examine the relationships between a drug, the biological system and the disease process. • Monoclonal antibodies ● Immunogenicity Y ● Bi-specifics Complement system Neuro-immunity Immuno-oncology ● • Combination therapies • IL-2 TIGIT • CAR T-cell therapies ● Vaccines Increasing complexity • COVID vaccines • Respiratory ● syncytial vaccine Oncology vaccine Neurodegenerative diseases ● ● ● ● Alzheimer's Parkinson's Multiple sclerosis Schizophrenia ● Gene therapies ● XX AAV vector delivery Hemophilia Fabry disease • Gaucher disease 42 CERTARA

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