Orthofix Investor Presentation Deck

Meaningful Revenue & Cost Synergy Opportunities Est. Revenue Synergies: >$25M >$200M base of complementary revenue between motion preservation, 7D enabling technologies, and BGT creates immediate pull-through opportunity International cross-selling: Orthofix Spine & Orthopedic established commercial channels + SeaSpine biologics & 7D Flash Navigation Expanded breadth of product portfolio to support large distributor conversions Increased product offerings per procedure Expected Cost Synergies: $40M² Reduction of redundant overhead, and public company costs Supply chain efficiencies ORTHOFIX®™ SeaSpine. Working Capital and CapEx Synergies Efficiencies through economies of scale in spinal implant set and inventory asset utilization Revenue Risk to Manage: $20M¹ Estimated dis-synergy risk from geographic overlap with opportunity for channel optimization, improved asset utilization, and forging new partnerships ¹Based on due diligence, including revenue zip code analysis performed by 3rd party 2Cost synergies of $40M expected by Year 3 with incremental opportunity to reduce stock-based compensation expense 17

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