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Ocuphire Pharma Results

Diabetic Retinopathy At a Glance Current Treatment Landscape Demonstrates Need for Less Invasive Therapies 4.HO 111 MAMMA There are ~8M adults in the U.S. with DR¹ The number of people with DR expected to increase more than 14M by 2050 Ocuphire PHARMA DR/DME affects about 1 in 4 people with type 1 and type 2 diabetes O 56% of patients reported anxiety related to anti-VEGF treatment DR is the leading cause of blindness among working-age adults $13B (2020) Global Intravitreal Injection Revenues in AMD, DME and BRVO4 If untreated, DR can rob people of their vision prematurely2,3 Majority of moderate to severe patients with DR are not treated with anti-VEGF due to injection fear and burden Source: 1. American Diabetes Association; International Diabetes Federation; Healthline; *Ocuphire internal analysis and assumptions; 2. Das UN. DME, retinopathy and age-related macular degeneration as inflammatory conditions. Arch Med Sci. 2016;12(5):1142-1157. doi:10.5114/aoms.2016.61918 3. Patient survey adapted from Lions International Foundation and International Diabetes Foundation-Europe; Meltzer 2000 4. Guidehouse Triangulation of Global Data, Market Scope and Investor Forecasts (2020) AMD = Age-Related Macular Degeneration; DME = Diabetic Macular Edema; BRVO = Branch Retinal Vein Occlusion 19
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