Evotec Investor Day Presentation Deck
evotec
Human PK and dose prediction
• Multispecies prediction
Improve quality and reduce costs to accelerate to INDs
Development readiness: discovery to development continuum
Target tissue concentration
Continuum of predictions to optimise
human PK during discovery process
Predicting solid state
• Design for solubility, polymorphism
screening & crystallisation processes
• Batch physical purity & crystal
structure determination
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Vein
Portal Pancreas
Gut
t
(faka)
Spleen
R
Venous Blood
Muscle
Kidney
R
K
Telt
QTA
CL
Arterial Blood
In Silico Relative Solubility Solvent Screening of Structure 1 @25°C
Nared to the best solvent
Predictive sciences drive faster and higher quality IND
R
Luno
R
Building development into Dx chemistry
• >13,808 development transformations
in a Dx reactions database
Right First Time approach = no reengi-
neering of process route for development
Drug-induced liver injury
Library of toxicology profiles
• Integrated Al and machine learning
to enhance predictive power
Unrivalled mechanistic insight
●
Action
Ectrophilic reaction of
126
Aside formation
R
AI
Alle An
11 SE
X-OBLOm
->>
GOPA
Accuracy 78-82%View entire presentation