Comera Investor Presentation Deck
SQore Well-Positioned vs. Other Approaches
SQore technology does not alter the structure or physical form of antibodies in solution, reducing
drug product development uncertainty, time and expense vs. some other approaches
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Score approach
TM
SQore excipients do not bind to antibody
No structural or chemical change to antibody
Antibody remains as a true solution with no
particulates
No expected impact to mAb absorption or
distribution after SQ administration
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Comera
LIFE SCIENCES
Other viscosity reduction
approach examples
Alteration of protein conformation or chemistry
(e.g. dehydration, resuspension)
Alteration of delivered solution (e.g. non-
aqueous microparticle suspension)
Impact to mAb absorption or distribution after
SQ administration potentially unknown
Approaches that either alter mAb structure/function or the physical form of the antibody itself
raise new scientific issues that may increase development risk, cost and timeline
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