argenx SE Investor Day Presentation Deck
Passive Transfer Model Highlights Toxicity of Bullous
Pemphigoid Autoantibodies
argenx
WT
FcRn
Mice injected with BP180 Ab
e
d
HDIG: High-dose human lgG
Li et al., J Clin Invest. 2005
HDIG lowers BP180 Ab levels and improves disease scores
=+IgM
+ HDIG
e
Serum R530 IgG level
(relative OD reading)
2.8
2.4
2.0
1.6
1.2
0.8
0.4
0.0
li
1 2
HDIG dose
(mg/g body wt)
3 4 5
0 0 0.5 1.0 2.0
WT FcRn
Clinical disease score
(mean ± SEM)
Anti-mBP180
Control IgG
0.0
2.5
2.0
1.5
1.0
0.5
Pathogenic autoantibodies induce typical skin lesions in murine passive transfer model of bullous pemphigoid
Mice injected with BP180 Ab
FcRn -/-: Degradation of BP180 Ab
0.0
HDIG dose
(mg/g body wt)
0.4 0.8 1.2 1.6 2.0 2.4
Serum anti-mBP180 lgG level
(relative OD reading)
FcRn-knockout mice show fast elimination of pathogenic autoantibodies and are resistant to disease
1
0
2
0
+IgM
+ HDIG
**
4 5
3
0.5 1.0 2.0
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