3Q22 Investor Update

■ ■ ■ ■ POSITIONING GVB FOR GLOBAL LEADERSHIP Capacity expansion plus industry leading certifications positions GVB as the supplier of choice. Prineville extraction facility will greatly reduce crude costs and support increased isolate margins at our Grass Valley facility. Prineville to come online during Q4 2022 / Q1 2023 and steadily scale production volumes throughout the year. FDA has committed to advance regulatory standards and product recommendations on CBD use in consumer and nutraceutical products. This standard will open the massive consumer products market that is already developing - 22nd Century will lead in certified facilities. Pursuing pharmaceutical grade API and additional certifications differentiating GVB distillates and isolates Ž 22ND CENTURY GROUP 15

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